The Red Sox, limited to two singles over the first five innings by Garza, finally broke through in the sixth.
Kevin Youkilis led off with a double, his sixth consecutive time on base (five hits, one walk), and took third on a fly by J.D. Drew. Jason Bay jumped on an 0-and-2 pitch and blasted it into the center-field triangle for a triple, trimming Tampa Bay’s lead to 4-1.
But the Sox couldn’t get Bay home from third as Mike Lowell lined to second and Jed Lowrie flied to left.
Matsuzaka threw 100 pitches in 5 1/3 innings before being relieved by Manny Delcarmen. Seven of the nine hits Matsuzaka allowed went for extra bases. He also walked three batters, hit one, and tossed a wild pitch.