The Orioles exploded for seven runs in the second inning against an ineffective Brad Penny to seize a quick 7-0 lead.
Ty Wigginton started the rally with a ground single to left, and Luke Scott slapped another single inside third base. Penny walked Gregg Zaun to load the bases and then walked Ryan Freel on four pitches to force in the first run.
Cesar Izturis lined out to third for the first out, but Brian Roberts lined a single to left to make it 2-0 and keep the bases loaded. After another four-pitch walk to Adam Jones forced in another run, Nick Markakis blasted a grand slam into the center-field bleachers to cap the uprising.