The Rays extended their lead over the Red Sox to 3-0 in the top of the third when Matsuzaka surrendered his second homer in as many innings. Pesky Akinori Iwamura opened the inning by drawing a walk and stealing second while Carl Crawford struck out. Evan Longoria lobbed a homer into the Monster Seats, his second homer of the series and giving him five RBI.
Matsuzaka allowed only 12 homers in 167 2/3 innings in 2008.